With such a long journey, we would like to give you some advice: you can look for a flight to Brussels, or if your budget is limited, you can check night buses and trains to save the daytime for your visits.
When do the first and last buses from Rome to Brussels leave?
The earliest time you can leave from Rome is at 09:04, while the last bus is at 20:04. The journey takes on average 25 hours and 3 minutes but it can also last 23 hours and 15 minutes with the fastest connections.
Which companies can you travel with from Rome to Brussels?
Virail counts among its partners also FlixBus, with buses from Rome to Brussels.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.