If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
Since the journey from Milan to Lyon is not so long, the bus is a good solution, but if you are looking for more offers or departure times, you can also have a look at trains and carpooling solutions.
What time are the buses to Lyon?
To get to Lyon from Milan by bus, it will take you around 7 hours and 3 minutes, or even 6 hours and 15 minutes if you choose the fastest solutions. The first bus leaves Milan at 05:05, while the last one is at 23:05.
Which bus lines can take you from Milan to Lyon?
There are many companies cooperating with virail, among which also FlixBus, Marino and Ouibus with buses to Lyon.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.
Marino is an Italian company mostly active in Southern Italy, but providing bus connections driving up to Northern Italy and also to France, Switzerland and Germany.