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The route from Messina to Rome is served daily by 4 bus departing from the stations of Messina Main Train Station, Messina Bus Stop, Fermata Dell'autobus Messina and arriving to the stations of Rome Tiburtina, Largo Guido Mazzoni, 3, Via Tiburtina.
The average duration of the journey is 9 h 58 min. The first bus leaves at 12:05pm. The last is at 10:30pm.

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