If there are changes in your route, make sure you always have enough time to walk from one platform to the other and never forget the possibility of delay that could make you miss the second train.
When it comes to relatively long journeys like between Nantes and Lyon, you can can consider taking a high-speed train or a plane to cut your journey's duration.
Which stations do the trains to Lyon leave from?
The trains to Lyon will leave from NANTES and will arrive at LYON-VAISE, Lyon Perrache or Lyon Part Dieu.
Travelling by train to Lyon from Nantes: how many daily connections are there?
How long does it take from Nantes to Lyon and when do the trains leave?
With the fastest connections you will be in Lyon in 4 hours and 28 minutes, but on average it takes 5 hours and 19 minutes. The first train headed to Lyon is at 04:04, while the last one leaves Nantes at 15:04.