Don't forget to buy food and drinks in advance if you need them: train stations do not always have shops, while onboard cafés are not always available and often very expensive.
Since the journey between Marseille and Lyon is relatively short, you can consider carpooling or bus as alternative ways of transport with cheapest prices and similar duration.
What are the departure and arrival stations in Marseille and Lyon?
The trains to Lyon will leave from Marseille Saint-Charles and will arrive at Lyon Part Dieu.
What time do the trains to Lyon leave and how long is the journey?
With the fastest connections you will be in Lyon in 1 hour and 46 minutes, but on average it takes 3 hours and 16 minutes. The first train headed to Lyon is at 05:07, while the last one leaves Marseille at 20:07.