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The route from Cologne to Prague is served daily by 25 bus departing from the stations of Cologne South, Airport, Cologne North, Leverkusen and arriving to the stations of Prague ÚAN Florenc, Prague Anděl, Prague ,Hradčanská, Prague Main Railway Station.
The average duration of the journey is 13 h 20 min. The first bus leaves at 12:10am. The last is at 11:35pm.

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