If you don't feel like spending many hours in a train, you can consider travelling by plane. Especially if you have the possibility to book in advance, flying to Orta San Giulio can be definitely cheap.
Which stations serve the rail line Palermo - Orta San Giulio?
The trains to Orta San Giulio leave Palermo from Palermo Centrale and arrive in Orta-Miasino.
Travelling by train to Orta San Giulio from Palermo: how many daily connections are there?
3 train connections exist to reach Orta San Giulio from Palermo per day. Please be aware that among these connections there are 3 routes with at least a change versus zero direct lines. So you will have to take another train.
How long does it take from Palermo to Orta San Giulio and when do the trains leave?
The average duration of the journey is 20 hours, but the fastest connections take you to Orta San Giulio in 17 hours and 21 minutes. The first train leaves from Palermo at 12:10, while the last one leaves at 21:10.