If there are changes in your route, make sure you always have enough time to walk from one platform to the other and never forget the possibility of delay that could make you miss the second train.
With such a long journey, you could take into account travelling by plane, which is not necessarily more expensive. Doing so, you will shorten the distances and you will be able to enjoy more time in Frankfurt.
Which stations serve the rail line Milan - Frankfurt?
You can take the train to Frankfurt at Milano Centrale, which arrives at Frankfurt(main)hbf, Frankfurt(main)sued or Frankfurt(Main)Hbf.
How many train connections exist to go from Milan to Frankfurt per day?
11 train connections exist to reach Frankfurt from Milan per day. Please be aware that among these connections there are 10 routes which have at least one change versus 1 routes which are direct lines. So although the trip is longer, if you want to travel between these cities at the last moment, choosing a route including one change or more could be better especially if there are too few connections. Nevertheless, if you do not want to change trains, it is highly advocated to choose an offer with a direct route.
How long will it take you from Milan to Frankfurt by train and when do the trains leave?
The first train to Frankfurt leaves at 11:10, whereas the last one at 18:10. On average, the journey lasts 8 hours and 26 minutes, but with the fastest connections you will be in Frankfurt in 7 hours and 35 minutes.