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The route from Messina to Palermo is served daily by 51 trains leaving from from the stations of Messina Marittima, Messina Centrale, Ponte Schiavo, Fiumara Gazzi, Tremestieri and arriving at to the station of Palermo Centrale.
The average journey duration is 3 h 33 min. The first train leaves at 4:50am. The last one is at 7:55pm.

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