If you are flexible with your travel dates, always consider that you can buy extremely cheap train tickets if you avoid travelling in the weekends and if you choose to travel during the low season.
If you don't feel like spending many hours in a train, you can consider travelling by plane. Especially if you have the possibility to book in advance, flying to Rome can be definitely cheap.
Which stations serve the rail line Barcelona - Rome?
Trains leave Barcelona from Barcelona Estació de França and arrive at Roma Ostiense.
How many train connections are there from Barcelona to Rome every day?
If you need to travel to Rome from Barcelona please know that there are 2 train connections every day. Please know that absolutely all these connections have a change or more. Therefore, you will not stay in the same train for the whole trip.
How long does it take from Barcelona to Rome and when do the trains leave?
With the fastest connections you will be in Rome in 21 hours and 53 minutes, but on average it takes 22 hours and 37 minutes. The first train headed to Rome is at 05:01, while the last one leaves Barcelona at 07:01.