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The route from Prague to Madrid is served daily by 23 bus departing from the stations of Prague Florenc Central Bus Station, ÚAN Florenc and arriving to the stations of Madrid Mendez Alvaro Estacion Sur, Madrid Avenida De America - Bus Station, Estación Sur, Avenida De América Metro.
The average duration of the journey is 42 h 22 min. The first bus leaves at 9:00am. The last is at 10:30pm.

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