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The route from Brussels to Madrid is served daily by 45 bus departing from the stations of Brussels North Train Station, Gare Du Midi, Brussels South (Gare Du Midi), Bruxelles Nord, Gare Du Nord, Brussels Midi / Brussel Zuid East, Bruxelles, Midi, Brussels-North Station and arriving to the stations of Madrid Mendez Alvaro Estacion Sur, Avenida De América Metro, Estación Sur, Estación Sur - Mendez Alvaro, Madrid Airport (T4), Madrid, Madrid Est Sur.
The average duration of the journey is 25 h 45 min. The first bus leaves at 6:00am. The last is at 4:30pm.

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