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The route from Brussels to Madrid is served daily by 35 bus departing from the stations of Brussels North Train Station, Gare Du Midi, Gare Du Nord, Bruxelles Nord, Bruxelles Midi, Brussels Midi / Brussel Zuid East and arriving to the stations of Madrid Mendez Alvaro Estacion Sur, Estación Sur, Avenida De América Metro, Madrid Est Sur.
The average duration of the journey is 26 h 30 min. The first bus leaves at 6:00am. The last is at 4:30pm.

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